8BKG33 · 6 credits · Basic level (G2X) · Medicinsk biologi
Gene Technology and Transgenic Models
Active · next start VT 2027
98%
passed the latest regular sitting
33PE · 2 Apr 2026 · 42 students
98%
passed the regular sittings, all sittings over the last 5 years
33PE · 211 students
10%
Harder than 10% of courses at basic level
Compared with 874 courses at the same level, ordinary exams over the last three academic years. 88 students.
Part of 1 programme
Other module
33PE Practical examination
- 5
- 4
- 3
- U
Main rounds
98% passed · 211 students
- 98%42
- 96%46
- 100%44
- 98%48
- 100%31
Later rounds
No sittings with at least 5 students.
- Get 4 or 5: 93% (211 students)
Show small sittings (1)
Sittings with fewer than 5 students, often credit transfers or special sittings. They are not part of any figure on this page.
- 100%1
Other modules
Partial exams, hand-ins and labs. They are not part of the figures at the top.
Other module
33WE Written examination
- 5
- 4
- 3
- U
Main rounds
89% passed · 208 students
- 97%38
- 85%46
- 91%47
- 90%49
- 79%28
Later rounds
77% passed · 13 students
- 77%13
- Pass a later round: 77% (13 students), compared with 89% (208 students) on the ordinary exam
- Get 4 or 5: 69% (221 students)
Show small sittings (9)
Sittings with fewer than 5 students, often credit transfers or special sittings. They are not part of any figure on this page.
- 100%3
- 67%3
- 100%2
- 67%3
- 75%4
- 100%3
- 0%2
- 75%4
- 67%3
Other module
33CE Compulsory elements
- G
- U
Main rounds
97% passed · 174 students
- 97%37
- 91%46
- 100%43
- 100%48
Later rounds
100% passed · 31 students
- 100%31
- Pass a later round: 100% (31 students), compared with 97% (174 students) on the ordinary exam
Show small sittings (6)
Sittings with fewer than 5 students, often credit transfers or special sittings. They are not part of any figure on this page.
- 100%1
- 100%3
- 100%2
- 100%1
- 100%1
- 100%1
About the course
Aim
Knowledge and understandingOn completion of the course, the student shall be able to:
- Describe methods of genetic modification in mammals.
- Describe the importance of genomic context to the expression of genes and transgenes.
- Understand developments that have resulted in modern transgenic approaches.
- Explain how different transgenic models can be used to elucidate specific disease mechanisms.
- Understand the limitations and possibilities of transgenic disease models.
Skills and abilitiesOn completion of the course, the student shall be able to:
- Plan strategies for the genetic manipulation and isolation of mutants in various model organisms, including fruit flies, yeast and mice.
- Identify potential problems of various transgenic strategies within biomedical research.
- Apply genetic engineering tools to manipulate the genome and the transcriptomes of human cells.
- Critically evaluate the results of biomedical research based on transgenic models.
Judgement ability and approachOn completion of the course, the student shall be able to:
- Demonstrate a well-founded and critical approach to assessing the advantages and disadvantages of using various transgenic methods in order to solve specific biomedical problems
- Evaluate ethical problems pertaining to the use of transgenic models in biomedical research
Content
The aim of the course is to introduce newly developed and popular methods of genome editing, including CRISPR/Cas9 and related systems, that exist today and to illustrate their potential significance to modern medicine. Gene expression analysis is also included as an approach to phenotyping cells and organisms. Specific emphasis will be placed on the historical developments that have made these techniques possible. Mouse systems are generally used as the model when studying human disease mechanisms, and the course will therefore focus primarily on these models but will also cover other model systems in which genetic engineering is often applied. The laboratory sessions will focus on the manipulation of embryonic stem cells from mice as a key step in generating genetically modified mouse lines. The course encompasses Mendelian genetics, recombinant DNA technology and methods relating to programmable nucleases. The course encompasses the fields molecular biology and medical genetics.
- Examiner
- Marcin Szczot
- Main field of study
- Medicinsk biologi