Biotechnology Manufacturing

Aim

Fundamental understanding of industrial biotechnology with focus on products such as drugs, food, chemicals, renewable energy sources and instruments and process equipment. Understanding of metabolic and cell biological processes from engineering perspectives.

After the course the student shall be able to:

• Describe the fundamental biological and engineering principles for production of proteins, metabolites and cells and devices and apparatuses.
• Carry out engineering computations and simulations of bioprocesses based on physical, chemical and biological fundamentals using basic mathematical equations and models.
• Execute the production of a recombinant protein and model its production process.
• Present results in oral and written form.

Content

• Biochemistry and physiology of cell growth and metabolism. "The Cell Factory" concept. Bioreactor design for batch, fed-batch and chemostat. Purification and separation processes. Using dynamic models and differential equations based on balances and microbial kinetics.
• Design of unit operations for cultivation and bioseparation. Typical industrial bioprocesses are illuminated (e.g. production of antibiotics, biogas, industrial enzymes, therapeutic proteins, vaccines, mammalian cells, stem cells and environmental applications).
• Calculations, mathematical modelling and simulation of bioprocesses.
• Practical laboratory: protein production and process modeling.